Phil Lesh Brings Fishman, McConnell, Russo, Osborne, & So Many More Friends To LOCKN’ [Full Set Audio]

first_imgSaturday’s LOCKN’ introduced the highly anticipated first set from Phil Lesh & Friends. The only member of the Grateful Dead on the festival site, the bassist held it down strong with an exceptional cast of characters, including: drummer Jon Fishman and key-master Page McConnell of Phish, drummer Joe Russo, guitarist Anders Osborne, and virtually all of The Infamous Stringdusters. The set included Dead favorites “Scarlet Begonias”, “Uncle John’s Band”, “Shakedown Street” and a heavy-hitting “Terrapin Station” to close things out. Fans were treated to husband and wife Derek Trucks and Susan Tedeschi for “Mr. Charlie” and “Sugaree”. You can listen to the full set below, courtesy of taper quinfolk:last_img

Target: New ways to battle disease

first_imgFor decades, developing medicine to treat disease was a lengthy and often discouraging process: create a drug, test on a lab animal, hold a human clinical trial, and hope to calibrate an effective dose to kill the disease without devastating the patient.Now, researchers at the Broad Institute of Harvard and the MIT are tapping the human genome mapped by its founders, hoping to create effective treatments for vexing afflictions.“When you rely on biology — not models but real humans — to reveal the root cause of the disease, the good news is you can discover insights for even the most daunting ones, like schizophrenia,” said Stuart L. Schreiber, Ph.D. ’81, director of the year-old Center for the Science of Therapeutics.Schreiber made his remarks Wednesday during a presentation on “The Road to Vital Therapy,” part of the Broad’s midsummer science lecture series. More than 500 people registered for the event, which focused on the institute’s efforts in what it called “chemistry-enabled, patient-based drug discovery.”Schreiber, who is also Morris Loeb Professor of Chemistry and Chemical Biography at Harvard, said drug discovery over the past 40 years has been a “daunting” process that can take as long as 15 years, fail 90 percent of the time, and often miss its mark.“When you rely on biology — not models but real humans — to reveal the root cause of the disease, the good news is you can discover insights for even the most daunting ones, like schizophrenia,” said Stuart L. Schreiber.Rather than focusing on traditional experiments, Broad researchers look to biology and chemistry — what Schreiber called “experiments in nature.” One is underway on Crohn’s disease, a painful inflammatory bowel ailment that afflicts as many as 700,000 Americans; it is expected to yield fruitful results.Broad researchers know that some Crohn’s genes are normal, some are not, and others protect against the disease. The institute’s goal is to find a drug therapy that fixes the gene that gives a person Crohn’s.Schreiber said a remaining challenge is that the work identifying genetic targets is too advanced for the chemists devising medical therapies. The Crohn’s gene target “pocket” that would hold the medicine is three-dimensional, while most drugs are two. Broad scientists are working on a solution.Genomic information isn’t a magic elixir, though. James E. Bradner ’94, associate director of the Center for Science of Therapeutics and an investigator at the Dana-Farber Cancer Institute, said that researchers thought when the human genome was sequenced, drugs could be made for each cancer-causing mutation.It turns out that there are a million unique cancer mutations in 24,000 genes. Many are passenger mutations — those caused by “smoking, chewing tobacco, breathing air, or bad luck.” At least 480 contribute to cancer, while 149 are known to cause it, Bradner said.Like Schreiber, Bradner believes that new drugs aimed at single genetic targets are the answer, when the technology to create them catches up.“We need new technologies, multiple avenues of therapy targeting these” mutations, said Bradner, a physician-scientist who is also an assistant professor at Harvard Medical School. “One of the obstacles is we may not have the technology we need.”Schreiber, speaking afterward, said he is hopeful that genomics and chemistry can be integrated to develop drugs to undermine stubborn diseases.“I’m optimistic because there’s a blueprint, a roadmap to get there,” Schreiber said. “It’s not going to be easy, but it’s very different from 10 years ago, when you didn’t know how difficult or easy it would be when you didn’t have the roadmap. Now, we just need to keep a laser focus.”Vivian Siegel, director of education and outreach, moderated. Alykhan Shamji ’00, Ph.D ’05, executive director of the Broad’s Center for the Science of Therapeutics, Michael A. Foley, director of the Therapeutics Platform, and Brian Hubbard, director of the center’s Therapeutics Projects Group, also were on the panel.The next lecture in the series, “Exploring the Genome’s ‘Dark Matter’: What the Frontiers of Genomic Research Are Revealing About Cancer,” is 6-7 p.m. July 17. It is free and open to the public.last_img read more

Suspects Detained in Attack Against Colombian Former Minister

first_img Colombian authorities announced on August 28 the capture of the five perpetrators involved in the explosive attack that took place in the month of May, against a former minister, and stated that, although they are not members of the FARC, this guerrilla group remains the main suspect in the attack. One of those arrested is a 16 year old who allegedly placed an explosive in the former Minister Fernando Londono’s armored van, which took the lives of two of his bodyguards and wounded nearly 50 people in Bogotá, reported the National Police Director José Roberto León, in a press release. The five arrested in this operation developed in recent days, formed part of a criminal organization, which was operating out of the city of Cali (southwest), noted León. Colombia’s Attorney General, Eduardo Montealegre, indicated that it still needed to determine and arrest the masterminds of the attack on May 15, against Londono, the Interior Minister (2002-2004) under President Álvaro Uribe. Montealegre, who in June blamed the attack on the FARC (Revolutionary Armed Forces of Colombia), reiterated that the insurgent group remains the main suspect. The reasons for this hypothesis is “the methodology that was used, which was a sticky (tape) that previously had been used by the FARC; the threats against Londono detected in emails and computers, and the existence of a failed FARC attempt years ago against the former Minister” argued Montealegre. President Juan Manuel Santos initially reported the arrest of seven “common criminals” in the operation, but later corrected that figure to five. Santos announced Monday that his government held talks with the FARC for eventual peace negotiations to end the armed conflict of almost half a century. By Dialogo August 30, 2012last_img read more

Golf course offers picture perfect backdrop for Gold Coast home

first_imgThe kitchen has a HUGE island bench – perfect for cooking up a storm.More from news02:37International architect Desmond Brooks selling luxury beach villa17 hours ago02:37Gold Coast property: Sovereign Islands mega mansion hits market with $16m price tag2 days ago“The property is in a beautiful spot,” she said. “You feel like you’re in a resort every day of the week.”The owners built the four-bedroom, two-bathroom home in 2015.Mrs Fea said their family had since outgrown the property so needed to sell to buy a larger one.“They’ve got a growing family and they need more yard for their children and a bigger property.”The living areas are open, perfect for entertaining. Plenty of space to avoid fights for the bathroom each morning.It has multiple living areas, including an upstairs retreat and family room overlooking the golf course.The kitchen includes Caesarstone benches, a butler’s pantry and Technika appliances.It also has a ducted vacuum and airconditioning system, solar hot water and a triple-car garage.The Hope Island Resort pool and parklands, shops, cafes, marina, fitness centre and tennis academy are a short buggy ride away.The view of the golf course isn’t bad! The home at 9105 Peter Senior Drive.MANICURED grass and surrounding trees offer a picture perfect backdrop for this Hope Island home.It is this position on the outskirts of The Links Hope Island golf course that makes the two-storey home at 9105 Peter Senior Drive such a peaceful place to live.Hum and Fea Realty principal Ruth Fea, who is marketing the property, said its location made it attractive to prospective buyers.Watch the sunset over the golf course from the outdoor entertainment area.last_img read more

Chinese study finds link between abortion and depression

first_imgLifesite News 19 Mar 2012A new study of post-abortive women in China found a high correlation between induced abortion and depression among pregnant women, adding to the growing body of evidence that links abortion with negative mental health outcomes. The findings were reached by a team of Chinese researchers from Anhui Medical College who analyzed data that had been previously collected as part of an on-going study on child development. Their study, titled, “The Impact of Prior Abortion on Anxiety and Depression Symptoms During a Subsequent Pregnancy: Data From a Population-Based Cohort Study in China,” was published recently in the Bulletin of Clinical Psychopharmacology.The researchers used data from 6,887 pregnant women who had participated in the Annui Birth Defects and Child Development Cohort study between October 2008 and September 2009. 3,264 of those women had experienced a previous abortion. Most were induced abortions, although the data also included some women who had had spontaneous abortions (miscarriages).They found that pregnant women who had undergone an induced abortion of a previous pregnancy a year or more before their current pregnancy were 49% more likely to experience depression and 114% more likely to experience anxiety during their first trimester. If the abortion was more recent, the risk was 97% greater for anxiety in the first trimester, and 64% greater for depression during the second trimester. In comparison, the study found, women who had experienced a miscarriage did not appear to be at a greater risk for anxiety or depression than other pregnant women in the first and second trimester.http://www.lifesitenews.com/news/chinese-study-finds-link-between-previous-abortion-and-depression-among-prelast_img read more

Manuel Pellegrini walks out on press twice after heavy defeat at Tottenham

first_img It was as open as Pellegrini got, bristling again when asked whether people had got carried away by City’s early fine form. “We never talked that we are invincible,” he said. “We know the Premier League is always close games and very difficult. “Anyone can beat another team. We must continue working, we have 15 points, we try to get a victory in the next game.” An exceptional start to the season is beginning to be forgotten after home defeats to Juventus and West Ham were compounded in north London on Saturday. Unable to follow-up their comfortable Capital One Cup win at Sunderland and hold onto a first-half lead, they returned from Tottenham on the back of a 4-1 defeat. Manuel Pellegrini appears to be feeling the pressure after twice storming out on journalists following Manchester City’s third defeat in four matches. Pellegrini kept his counsel during the press conference, but his cool exterior dropped when the cameras were off and he spoke to the written press. The City boss stormed off after less than 30 seconds having quickly grown unhappy with questions about his post-match emotions – before making an embarrassing retreat having walked the wrong way. “If you want to talk about football, we talk about football, if not then no,” he said. “If you want to talk about football yes, but if you want to talk about stupid things then I do not answer stupid things.” Pellegrini would again storm off – this time through the right exit – after an innocuous question about Sergio Aguero’s performance, although the City boss did answer a few questions before that. The Chilean defended his centre-backs after the heavy loss – “I think they both played very well” – and said that enforced changes rather than under-performing players were the main issue. “It is difficult to keep a level when you must always make changes,” he said. “That is difficult. “We couldn’t continue playing with the same team. We have an important squad and maybe we made important mistakes in the last games.” Press Associationlast_img read more

Update on the latest sports

first_img May 9, 2020 UNDATED (AP) — The NHL is considering the prospect of holding its amateur draft before the Stanley Cup final.The draft had been scheduled for June 26-27, but it was postponed with the season in an indefinite suspension due to the coronavirus pandemic. Now the NHL is deciding whether to hold it earlier in June following the NFL’s success with its virtual draft last month.Such a move means teams would not be able to trade players before or during the draft, there would be a lack of clarity over next year’s salary cap and the draft order could be determined before all games are played. There are mixed feelings about the idea among executives.In other developments related to the coronavirus pandemic:— The end of this virus-disrupted school year has produced a bleak financial outlook for major college sports. Budget projections are landing in the red. West Virginia has announced a $5 million projected shortfall for the fiscal year ending June 30. The athletic director will take a 10% salary reduction for the next budget cycle along with other high earners in the department. Minnesota has forecast a $4 million deficit for the current fiscal period. The month before the pandemic hit, a $1 million surplus was projected. Now, the school says all cost-savings measures are on the table. Hamlin takes virtual finaleCHARLOTTE, N.C. (AP) — Denny Hamlin closed NASCAR’s iRacing Series with a victory at a simulation of throwback North Wilkesboro Speedway.This year’s Daytona 500 champion had four fresh tires as he chased down leader Ross Chastain and nudged him out of the way. Chastain retaliated by hitting Hamlin’s car after the checkered flag.Timmy Hill finished second, followed by Tyler Reddick, Chastain and Austin Dillon.Hamlin was instrumental in organizing his fellow Cup drivers for the invitational series that started after the series was suspended. He also won the opening iRacing event on March 22. Share This StoryFacebookTwitteremailPrintLinkedinRedditUFC-TRUMPTrump lauds UFC for resuming matchesJACKSONVILLE, Fla. (AP) — President Trump has congratulated UFC for restarting the sports world Saturday night after a nearly two-month hiatus. Hamlin races barefoot on a top-of-the-line simulator. He also gained national attention three races ago at virtual Talladega Superspeedway when his daughter, Taylor, tried to ask him a question during the race and accidentally turned off the screen on his simulator with a remote control she was holding.WOMEN’S BASEBALL-PRATT-OBITOriginal Rockford Peach diesBRAINTREE, Mass. (AP) — Former Rockford Peaches and Kenosha Comets pitcher Mary Pratt has died at 101.Pratt was believed to be the last surviving member of the original 1943 Peaches in the All-American Girls Professional Baseball League, which inspired the 1992 movie, “A League of Their Own.” She pitched in the league until 1947 and taught physical education for 46 years. Trump’s taped message was played during ESPN’s broadcast of the UFC 249 undercard from a fan-free arena Saturday in Jacksonville, Florida. He congratulated UFC President Dana White, who is a Trump business associate and a major contributor to his re-election campaign.UFC 249 served as the first major sporting event to take place since the global pandemic shut down much of the country nearly eight weeks ago. It was supposed to be held in New York April 18 but was postponed in hopes of helping slow the spread of COVID-19. White tried to stage the event on tribal land in California and still hopes to create a “Fight Island” for future cards.One of the fighters scheduled to take part in UFC249 has tested positive for the COVID-19. UFC says Jacaré Souza’s middleweight bout against Uriah Hall was called off after Souza tested positive, along with his two cornermen. UFC says all three men have left the host hotel and will be self-isolating off premises, where UFC’s medical team will monitor their conditions remotely.VIRUS OUTBREAK-SPORTSNHL considers early draft The league said in a tweet that Pratt’s “stories, her energy will be missed for a long time.”Her nephew, Walter Pratt, told The Patriot Ledger of Quincy, Mass. she passed away peacefully at a nursing home.OLYMPICS-JOVANOVIC-OBITUS bobsledder diesLAKE PLACID, N.Y. (AP) — Former U.S. Olympic bobsledder Pavle Jovanovic has died at 43. The Toms River, New Jersey, native took up the sport in 1997. A push athlete for driver Todd Hays, he won a bronze medal at the 2004 world championships and finished seventh in both the two- and four-man events at the 2006 Winter OlympicsUSA Bobsled/Skeleton said in a release Saturday that Jovanovic took his own life May 3. Update on the latest sports — Wisconsin athletic director Barry Alvarez, football coach Paul Chryst (krihst) and men’s basketball coach Greg Gard are being asked to take a 15% pay cut over the next six months as part of the school’s response to the pandemic. School officials say Alvarez, Chryst and Gard are among 25 of the athletic department’s highest-earning employees who are being asked to take that voluntary cut. There will be no reduction in that group’s work hours.— Watford chairman Scott Duxbury says at least six of the 20 English Premier League clubs are concerned about the plan to use neutral stadiums to finish the season. The Hornets have joined Brighton and Aston Villa in making clear their opposition to the current “Project Restart” concept ahead of Monday’s crunch meeting of topflight clubs. Teams at or near the relegation zone are worried about the monetary and competitive impact of playing the remainder of the season at neutral grounds without fans. “Project Restart” needs approval from at least 14 teams.— Two players at German second division side Dynamo Dresden have tested positive for the coronavirus, putting on hold the club’s planned return to soccer next weekend. Dresden was to play Hannover away on May 17 when the league resumes after a two-month suspension. Now, the entire squad, coaching and supervisory staff must go into 14 days of quarantine at home.— The president of French soccer club Lyon (lee-OHN’) says all members of its men’s and women’s teams have tested negative for the coronavirus. They were tested by team doctors.NASCAR-iRACING Associated Press last_img read more

Syracuse reportedly adds graduate transfer Whisper Fisher from St. Joseph’s

first_img Facebook Twitter Google+ Published on May 21, 2019 at 6:04 pm Contact David: [email protected] Former St. Joseph’s forward Whisper Fisher is reportedly transferring to Syracuse, according to her father, Matthew. Fisher, a graduate transfer, will be able to play immediately.“Whisper is excited about the chance play for coach (Quentin Hillsman),” Matthew said. “He’s one of the best player development and X’s and O’s coaches in the country.”Fisher’s move to SU marks the second transfer of her collegiate career. The Owings Mills, Maryland native played at Loyola Chicago as a freshman, where she appeared in 21 games and averaged less than a point and rebound per game. After sitting out the 2016-17 season due to NCAA transfer rules, Fisher spent two seasons at St. Joseph’s. She logged her best collegiate season in 2018-19, posting 3.8 points and 4.4 rebounds per game. The Hawks went a combined 31-34 in Fisher’s two years on the team.The addition of Fisher, 6-foot-2, will help fill the void left by standout forward Miranda Drummond, who graduated from SU in 2019. Drummond averaged 31.9 minutes and 14.1 points per game in two seasons at Syracuse and holds the Orange’s career 3-point field goal percentage record (40.2 percent).AdvertisementThis is placeholder text Commentslast_img read more

WHS Daily Bulletin: Any sophomore serving at Prom dinner needs to signup by Saturday

first_imgSubmitted to Sumner Newscow — Today’s Wellington High School bulletin for Wednesday, March 30, 2016:Wednesday•Fashion show at 9 a.m.•Lip Dub at 1 p.m.Thursday•JV golf at Winfield Country Club, 3 p.m.•JV tennis at Circle, 3 p.m.•Baseball at Mulvane, 4 p.m.•Softball at Mulvane, 4:30 p.m.Friday •Track at Clearwater 4 p.m.Today’s lunch — Burrito with sauce, romaine and tomato, sweet corn, pears, tortilla chips and milk.Tuesday’s lunch — Tater Tot Casserole, Tossed Salad with Romaine, Peas, Hot Roll, Chilled Peaches and MilkToday’s News: *Work Ethic Program Participants- You may attend the Fashion Show today as one of your sessions!*Any sophomore interested in serving the Prom dinner on Saturday, April 23rd, please sign up in the office.*Seniors: If you were unable to pick up your Senior Orders, please stop by the counselors office. The order will need to be paid in full before you can pick up your items. At this time no personal checks will be allowed- cash or money orders only. If you are going to pay by credit or debit card you will need to contact Jostens. If you have not ordered your cap , gown, stole and tassel and you want to participate in graduation ceremonies, please go to jostens.com to place your order. You will need to do this as soon as possible.* Senior Girls- Reminder- the PEO Scholarship application is due April 1!*Seniors: The Kansas All-Star scholarship application is now available on their website which is www.ksallstarsholarships.com. Those who qualify will be awarded a $1000 scholarship to be used toward their post-secondary education. Applications will be accepted now through April 15.Guidance news:Wednesday, April 20 – Butler Community Colleges.Today is National…National Little Red Wagon DayNational Doctors DayNational I am in Control DayNational Pencil DayFollow us on Twitter. Close Forgot password? Please put in your email: Send me my password! Close message Login This blog post All blog posts Subscribe to this blog post’s comments through… RSS Feed Subscribe via email Subscribe Subscribe to this blog’s comments through… RSS Feed Subscribe via email Subscribe Follow the discussion Comments Logging you in… Close Login to IntenseDebate Or create an account Username or Email: Password: Forgot login? Cancel Login Close WordPress.com Username or Email: Password: Lost your password? Cancel Login Dashboard | Edit profile | Logout Logged in as Admin Options Disable comments for this page Save Settings You are about to flag this comment as being inappropriate. Please explain why you are flagging this comment in the text box below and submit your report. The blog admin will be notified. Thank you for your input. There are no comments posted yet. Be the first one! Post a new comment Enter text right here! Comment as a Guest, or login: Login to IntenseDebate Login to WordPress.com Login to Twitter Go back Tweet this comment Connected as (Logout) Email (optional) Not displayed publicly. Name Email Website (optional) Displayed next to your comments. Not displayed publicly. If you have a website, link to it here. Posting anonymously. Tweet this comment Submit Comment Subscribe to None Replies All new comments Comments by IntenseDebate Enter text right here! Reply as a Guest, or login: Login to IntenseDebate Login to WordPress.com Login to Twitter Go back Tweet this comment Connected as (Logout) Email (optional) Not displayed publicly. Name Email Website (optional) Displayed next to your comments. Not displayed publicly. If you have a website, link to it here. Posting anonymously. Tweet this comment Cancel Submit Comment Subscribe to None Replies All new commentslast_img read more

Nations Cup team selected for British girls’ championship

first_img7 Aug 2012 Nations Cup team selected for British girls’ championship The trio of Gabriella Cowley, Georgia Hall and Brogan Townend will represent England in the Nations Cup team event at the British girls’ championship at Tenby from 13-17 August. The reserve is Olivia Winning. Gabriella, 16, from West Essex, is the Scottish U16 open stroke play champion and, like Georgia, Brogan and Olivia, is currently representing England in the Girls’ Home Internationals at Radyr, Wales. She was the 2011 English U15 titleholder. Georgia Hall, 16, (Remedy Oak), is currently ranked sixth in the women’s world amateur rankings. She was runner-up in the English women’s amateur in May and reached the semi-finals of the Ladies’ British Open Amateur Championship at Carnoustie in June. Brogan Townend, 18, (Pleasington, image © Leaderboard Photography) is the 2011 Faldo Series girls’ champion and this year’s  runner-up, for the second season in a row, in the Northern women’s championship. She has helped Lancashire reach the 2012 County Finals. Olivia Winning, 17, (Rotherham), had a top ten finish at the English girls’ championship. She won the Pleasington Putter and was runner-up at this season’s Fairhaven Trophies where she set a course recordlast_img read more