Adaptation of the melatonin rhythm in human subjects following nightshift work in Antarctica

first_imgDifferent environmental conditions, particularly daylength and intensity of natural light, may influence the ability of shiftworkers to adapt to the abrupt phase-shifts of 24 h time cues imposed by the nature of their work. We have investigated this problem in terms of the circadian rhythm of the pineal hormone melatonin in nightshift workers on the British Antarctic Survey Base at Halley (75° South). Melatonin production was assessed by measurement of its major urinary metabolite 6-sulphatoxymelatonin (aMT6s) by radio-immunoassay in sequential urine samples collected for 48 h at weekly intervals. The acrophase of the melatonin rhythm was significantly delayed from 5.22 h.min to 14.54 h.min (summer) and 8.73 h.min to 13.23 h.min (winter) during a week of night-shift work. Readaptation of the rhythm following night-shift work was markedly slower during the Antarctic winter taking 3 weeks compared to summer where the baseline phase position was re-established after 1 week. Morning and evening treatment (08.00–09.00 h, 16.00–17.00 h) with bright (> 2500 lux) full spectrum white light did not significantly modify this phenomenon in summer, but a trend to faster adaptation with light treatment was seen in winter. These observations are likely to be of importance to shift-workers in temperate zones. Further investigations of phase-shifting techniques, such as appropriately timed bright light and administration of melatonin itself, are indicated, particularly in relation to performance at work.last_img read more

Lettings sector to face huge reforms designed to weed out rogue agents

first_imgHome » News » Lettings sector to face huge reforms designed to weed out rogue agents previous nextRegulation & LawLettings sector to face huge reforms designed to weed out rogue agentsHousing ministry outlines compulsory code of conduct including mandatory training, new regulator and sweeping reforms of leasehold.NIgel Lewis3rd April 201801,991 Views A new compulsory code of conduct for agents backed by mandatory qualification for at least one member of staff and a new independent regulator have been announced for the lettings and property management sectors by the Ministry of Housing, Communities and Local Government (DHCLG).The details of the new code will now be thrashed out by a working group of lettings, tenant and regulatory representatives, with proposals nailed down by early 2019.The DHCLG announcement, which was released during the Easter break, revealed that it wanted to protect the UK’s nine million private renters from the unexpected costs, vague bills and poor quality repairs offered by rogue agents.“Most property agents take a thorough and professional approach when carrying out their business, but sadly some do not,” says Housing Minister Heather Wheeler (pictured, left).“By introducing new standards for the sector, we will clamp down on the small minority of agents who abuse the system so we can better protect tenants and leaseholders who find themselves at the end of a raw deal.Other measures outlined by the DHCLG include the promised reform of leasehold including a new system to help leaseholders challenge unfair fees, help to switch managing agents where the service is poor and a requirement for managing agents to undertake professional development and training.The working group will also consider a cap or ban on the ‘additional charges’ many freeholders and leaseholders face including restrictive covenants, leasehold restrictions and administration fees.Industry reaction“This is incredibly welcome news to protect tenants and leaseholders from a small minority of rogue agents,” says Gerry Fitzjohn (right), Chairman of The Property Ombudsman.“Tenants have little choice over which agent they deal with as they often choose a property first and then have to use the agent which is managing it. These reforms however, will create a level playing field for consumers who will finally be able to expect a consistent level of service and knowledge, regardless of which agent they choose. This will also help consumers feel more empowered to raise concerns if necessary.“We also welcome the news that civil penalties will be introduced for those that fail to comply with Client Money Protection. The requirement to share data across providers, redress schemes and local authorities to ensure compliance will help with enforcement and protect consumers.”Isobel Thomson (left), CEO of NALS, says: “We welcome the Government’s recognition of the current contribution that lettings and management firms play within the Private Rented Sector (PRS).Creating a level playing field will eliminate the poor practice and dishonesty that currently tarnishes the sector and ensure a safe and fair experience for tenants and landlords.“NALS has consistently called for regulation and unreservedly supports the Government’s announcement of its intentions and strategic goals. Agents who already submit to self-regulation should have nothing to be concerned about. NALS will continue to be at the forefront of discussions over the Government’s route map.” letting agents regulation heather wheeler Communities and Local Government department of housing dhclg April 3, 2018Nigel LewisWhat’s your opinion? Cancel replyYou must be logged in to post a comment.Please note: This is a site for professional discussion. Comments will carry your full name and company.This site uses Akismet to reduce spam. Learn how your comment data is processed.Related articles BREAKING: Evictions paperwork must now include ‘breathing space’ scheme details30th April 2021 City dwellers most satisfied with where they live30th April 2021 Hong Kong remains most expensive city to rent with London in 4th place30th April 2021last_img read more

Postdoctoral Associate – Pediatrics – Dr. Eric Nelson’s Laboratory (55389)

first_imgA postdoctoral research position is available in the laboratory ofEric Nelson, M.D., Ph.D. at the Emerging Pathogens Institute,University of Florida. The overall goal of our laboratory is todevelop better methods to improve the care, diagnosis andmanagement of patients during large-scale diarrheal diseaseoutbreaks. Our model system is cholera and our primarycollaborative field sites are in Bangladesh and Haiti. In thefield, our research focuses on identifying and characterizing keyselective pressures that drive disease severity and transmission.At the University of Florida, we test hypotheses derived from thefield studies in animal models of infection and transmission.The current available project lies at the physiologic interfacebetween host and pathogen. Specifically, the first phase ofresearch involves characterizing the microbiota of human diarrhealdisease samples and identifying antimicrobial factors important topathogenesis and transmission (e.g. antibiotics by LC/MS andbacteriophage). Samples will be characterized for markers of smallbowel overgrowth, environmental enteropathy, and innate/ acquiredimmunity dysfunction. Descriptive findings will then be evaluatedfor causation in animal models using genetic manipulations ofpathogens of interest (e.g. Vibrio cholerae). The secondphase will involve two clinical studies. The first is to study theimpact of single-dose antibiotics on the microbiota inside andoutside the gastrointestinal tract during cholera infection. Thesecond study involves assessing a novel point of care diagnosticfor V. cholerae. The clinical studies will requireintermittent field research.The position is available as soon as possible. The position is atleast one year and extension is contingent on satisfactoryperformance. Although this is a funded position, the candidate isencouraged to apply for additional funding.Laboratory information is available at: Ph.D. and at least 3 first-author publications in an indexedjournal are required. A molecular microbiology skill-set AND aninterest in global health are required. Experience with nextgeneration sequencing, bioinformatics (R), immunology, genedeletion/ complementation in bacteria, animal models of infection,project management and field research are desired.Email inquiries using the subject “Post Doc” to Dr. Eric Nelson ([email protected] ) arewelcome; however, applications must be submitted online.Review of applications will begin on November 22, 2019 and willcontinue until a sufficient applicant pool has beenestablished.Applications should include a cover letter/letter of interestincluding a statement of your research accomplishments andinterests, curriculum vitae, and list of three references.Selected candidate will be required to provide three letters ofrecommendation and an official transcript to the hiring departmentupon hire. A transcript will not be considered “official” if adesignation of “Issued to Student” is visible. Degrees earned froman education institution outside of the United States are requiredto be evaluated by a professional credentialing service providerapproval by National Association of Credential Evaluation Services(NACES), which can be found at .If an accommodation due to a disability is needed to apply for thisposition, please call 352-392-2477 or the Florida Relay System at800-955-8771 (TDD). Hiring is contingent upon eligibility to workin the US. Searches are conducted in accordance with Florida’sSunshine Law.#category=35The University of Florida is committed to non-discrimination withrespect to race, creed, color, religion, age, disability, sex,sexual orientation, gender identity and expression, marital status,national origin, political opinions or affiliations, geneticinformation and veteran status in all aspects of employmentincluding recruitment, hiring, promotions, transfers, discipline,terminations, wage and salary administration, benefits, andtraining.last_img read more

Archer at New

first_imgJeffrey Archer chose Oxford University as the venue for the relaunch of his political career. The peer and convicted perjurer addressed a meeting of the Howard League for Penal Reform held at New College on 18th September, suitably entitled “After Crime.” Speaking alongside University academics, Lord Archer proffered his insider knowledge on prisoner drug abuse and the need for incentives to increase education in prisons.ARCHIVE: 0th Week MT2003last_img

Keble kings retain crown again

first_imgMagdalen 3 – 18 Keble KEBLE re-asserted their authority in the world of college rugby after claiming their third successive Division One title on Tuesday. Magdalen went into the game with an outside chance of stealing their opponent’s crown but came unstuck against a Keble machine who have not lost a league fixture in two and a half years.Fittingly, given the importance of the match, Keble had by far their toughest outing this season against a combative and well drilled Magdalen team. Indeed, Magdalen’s structure and moves provided a touch of intrigue among some of the crowd, as it emerged that former Keble player and coach Winnie Humphreys was now managing their opposition. The home side started strongest, with clear intent to stamp their dominance on Keble before they built up momentum. Winning an early scrum, Andrew Barnes had Keble pinned down with some astute kicking. However, Magdalen’s failure to capitalise on territorial gains proved to be their undoing, as it was throughout the match.As the game swung back and forth between the respective 22’s,  Keble’s forwards made several powerful drives, attempting to break the deadlock. Reaping the benefit of these territorial gains with a penalty on 15 minutes, the Keble pack also powered over a try to cement their lead. Yet this half was far from one-way traffic, and just before half-time Magdalen clawed 3 points back with a late tackle on one Waite brother by the other. Barnes easily slotted the resulting penalty kick to gain a just reward for a fiercely contested first half.The second period was a similar battle of territorial control but again Keble’s sustained pressure reaped dividends as a penalty 10 minutes into the second half gave them  an 11 point lead. Picking up some momentum in the backline as the game opened up late into the second half, Keble completed a sweeping move. Starting from the centre and working the ball from right to left, Keble winger  Fox finished with an explosive dash to make the score 16-3. Peter Bolton then converted from a tight angle to hand Keble an 18-3 victory.  As is so often the case the score line obscures what was a closely contested encounter. Magdalen will rue their lack of finishing, especially given the strength of their pack whose performance exerted considerable pressure on the champions, particularly in the second half. However, Keble fly-half Pete Bolton’s metronomic boot kept his side out of trouble and formed the basis of their attacks with his devastating accuracy.Tellingly, Keble captain Max Cole suggested that while the game was well balanced, perhaps Magdalen’s game was too similar to a Keble side that had built up an immense head of steam ahead of this match. Magdalen captain Andrew Johnson conceded that Keble have had a “great season” and he can console himself that his side came far closer than the score line suggests to derailing this seemingly unstoppable Keble juggernaut that will be already thinking of a fourth title.last_img read more

7th Circuit Reverses Benefits Denial; Judge Chastises Process

first_imgJennifer Nelson for www.theindianalawyer.comSeventh Circuit Judge Richard Posner had harsh words for the Social Security Disability Office regarding vocational expert testimony: clean up your act.The 7th Circuit Court of Appeals reversed the denial of Anne Hill’s application for Disability Insurance Benefits and Supplemental Security Income, finding the administrative law judge’s credibility analysis was flawed. Hill, 56, worked for more than 13 years at a steel factory where she had to carry steel sheets weighing up to 100 pounds. The manual labor took a toll on her body and she applied for disability benefits in 2011. Her physical issues include total hip replacement, knee pain, recommended total shoulder replacement, and severe physical limitations in the use of her left side.She babysits, but is unable to lift the child, does chores and goes to church, but is unable to sit or stand for long periods of time.The vocation expert in her case testified that she could work at jobs classified as light and unskilled, such as dealer account investigator or a counter clerk. The expert, using his own experience to opine on how Hill’s issues with her left side would impact her ability to work, testified she could still perform sedentary jobs such as a registration clerk.Using the five-step analysis for assessing disability, the ALJ concluded Hill is not disabled. The ALJ noted that Hill was not taking narcotic pain relievers, but Hill had testified that was because of her past alcohol addiction.  The judge reasoned Hill exaggerated her back pain because she hadn’t been diagnosed with certain conditions, but that conclusion is not supported by any medical evidence in the record.“We are not confident that the ALJ would have reached the same conclusion about Hill’s credibility had she not inappropriately ‘played doctor,’ ignored possible explanations for Hill’s conservative treatment, and conflated a desire to work with the ability to do so. So the ALJ’s errors are not harmless,” Judge Anne Claire Williams wrote.Posner wrote a concurring opinion in which he focused on “a persistent, serious and often ignored deficiency in opinions by the administrative law judges of the Social Security Administration” in denying benefits. He noted the issues regarding vocational expert testimony concerning the number and types of jobs that an applicant deemed not to be totally disabled could perform.  It appears the experts simply divide census data estimates on the number of jobs in a broad category that includes the narrow category of jobs that the applicant can perform, by the total number of narrow categories in the broad category.“The assumption is thus that every narrow category has the same number of jobs as every other narrow category within the broad category – a preposterous assumption,” Posner wrote.“In short, the vocational expert’s testimony was worthless – and this apart from the apparent arbitrariness of his numerology,” he continued. “It is time the Social Security Disability Office cleaned up its act.”The case is Anne R. Hill v. Carolyn W. Colvin, acting commissioner of Social Security, 15-1230.FacebookTwitterCopy LinkEmailSharelast_img read more

Beach Replenishment Update: 52nd Street All Clear

first_imgThe beach at 52nd Street is empty on Friday (June 5), save for one CRAB (coastal research amphibious buggy).Check OCNJ Daily for updates and photos of the Ocean City beach replenishment project for 2015 in the south end between 37th and 59th Streets.DATE: Friday, June 5Metal cages used to filter debris from the dredging slurry and some other equipment is on the back of the beach at 55th Street on Friday, June 5.PROGRESS: As of Friday afternoon, the beach at 52nd Street was cleared of all pipeline and equipment except for the three-legged coastal research amphibious buggy (CRAB), which presumably will be moved as well. Crews were removing the pipeline down the beach and had reached about 54th Street. Some equipment was stored at the back the beach at 55th Street.The project is on hold for 6 to 8 weeks. Crews are working to minimize the impact on beachgoers during the standstill. Work stopped on Saturday (May 30) due to an engine problem on the hopper dredge that has been pumping new sand onto the beaches since mid-April. The Liberty Island at port in Norfolk, Va., as it awaits repairs.The first two phases of the project (from 42nd Street to 37th Street, then from 42nd Street to 47th Street) are complete.WHAT’S NEXT: The project will proceed from 52nd Street to 47th Street, then from 55th to 59th (target date for completion is Sept. 9).READ MORE: Ocean City NJ Beach Replenishment 2015 Daily UpdateFOR DAILY UPDATES by E-MAIL: Sign up for freelast_img read more

Aures shows terminal style

first_imgPoint-of-sale terminals and systems manufacturer Aures, unveiled its latest Epos terminals at the European EuroShop show, held in Germany earlier this month. The Odyssé II, launched under its Posligne brand, features a new set of colour clips in mocha, silver, cassis, iris and kiwi a choice to suit any shop design. The terminal base comes in pearl or graphite colours.The new Odyssé II has an even more powerful motherboard featuring an Intel Dual-Core E5300 processor). The terminals also include the HSD (Hardware Status Display) utility a new item providing an instant display of the key system data, including processor temperatures and power supply readings.last_img

Is This the Renaissance of the PC?

first_imgAround the year 2000, the term “tablet PC” was coined. Ten years later, in 2010, we saw the first headline – “The PC Officially Died Today” – and a near decade long debate began, with most tech pundits convinced that the PC would be extinct by 2020.Fast forward to today and the narrative has changed. Worldwide PC shipments increased 17.1% Y/Y in 3Q20 while smartphone shipments are projected to decline 1.3% Y/Y in the same quarter.¹ While the PC has always helped us connect, collaborate and communicate, 2020 has proven the value it brings to our lives more than any other time I can remember. This is a popular opinion – nearly everyone will agree – but I’d take it a step further. I believe we’re witnessing the renaissance of the PC. Not a resurgence, as that would imply a period of little activity, but a renaissance. An entirely new way to think about something.We’ve been designing innovative PCs that can help you “work from anywhere” for years, but we’ve been given a rare opportunity to step back, rethink and use this time as a catalyst for positive, innovative change.IT Doesn’t Touch the PCIt’s mind-boggling what IT teams have accomplished this year. Digital transformation initiatives went from multi-year projects to turning on like a light switch in a matter of days.We have always put the needs of people at our core, with support available at every stage of a company’s journey to provide a productive and connected digital workforce. With solutions like Unified Workspace, we provide ready-to-work PC experiences for employees, regardless of location. Our approach protects from security vulnerabilities, lightens and automates workloads, provides management options from DIY to managed-for-you, and provides support for the unexpected.But how does this evolve in our renaissance phase? Think of PCs that self-heal to keep you working instead of looking for help. Think how the combination of AI, analytics, the cloud and improved connectivity will make remote management of PCs a breeze. And how the promise of predictive maintenance means problems fix themselves before they manifest.A future where IT never physically touches a PC again? That’s a revival that could benefit us all.With AI, PC Now Stands for Personal CompanionWith ever-increasing demands, we need PCs that do more than just work. PCs that are more intelligent, self-aware and user aware. We recently introduced Dell Optimizer, our AI-based software that learns and adapts to how you work and provides faster app launches, extended battery life, and easier log-on and secure lock-outs.Future AI capabilities will benefit us in ways we haven’t yet imagined. . AI will make PC usage more seamless, customized and hassle-free. It will hurdle common tech challenges, like connecting to the local network or setting up a printer. Imagine ubiquitous connectivity and a continuous experience that translates across all your preferred devices so you can always pick up where you left off. Think about having a personal AI assistant on your PC to help manage your work and home life. Setting calendars appointments or making recommendations based on contextual data will be simple tasks completed in the background for you. A PC that becomes a trusted and reliable assistant, or personal companion, while you manage work and play from anywhere.Beyond Form Factor: Collaboration and Connectivity take the SpotlightThe industry has long focused on offering the smallest and lightest devices possible. At Dell, we’ve balanced the demand for compact form factors against the convenience of a variety of ports, long battery life and the connectivity options remote workers need. The themes of “work from anywhere” won’t change (think collaboration and connectivity), but the way they manifest will.As your PC gets more intelligent, it understands when you want to be seen and when you don’t. If you’re participating in a video conference but get distracted – it could be a phone call, or your officemate/partner/child/dog needs you – you can trust your PC to turn off the camera until you choose to re-engage.The space that you occupy at any given moment shouldn’t limit your productivity. Mobile PCs may offer expansive, adaptive screens so you can be more productive wherever you are. Think of workplaces that are completely wireless and turn on by detecting your presence, so you stay productive as you transition from on-the-go to at-the-desk.Remote workers need baseline internet connectivity and 5G availability is expanding. The Latitude 9510 is the first PC available on T-Mobile’s 5G network. However, we still need more PCs that can leverage 5G for anywhere, secure connectivity or that can default to 5G when Wi-Fi is slow. Collaboration and connectivity that make you feel like you’re with your colleagues when you aren’t — that’s the next frontier.PC Luxury Within Reach for AllIn the past, executives and salespeople would often get the top-of-the-line devices—the sleekest laptop with high-end components. I know we’ve all had a moment where we’ve gotten a little jealous of a colleague’s new device. When I think about a renaissance of the PC, I imagine us being able to bring these “premium” experiences to more employees. Our promise is that premium is more than the look and feel of a device, the evolving workforce is redefining it.Premium is about offering the features you care about like low blue light technology and privacy shutters for when you log many hours a day on your device. The unboxing experience also becomes important since IT may never touch the device. And once the PC is out of the box, we should all be able to jump straight into work the moment we power on.While Dell has focused on accelerating the circular economy for years and is vocal about our moonshot goals, there’s no slowing down when we look to the future. Better PC designs engineered for disassembly and material recovery will become more important. And look for more options like PC as a Service (PCaaS) that provide flexibility in IT spending, simpler ways to refresh to the latest PCs and peace of mind with secure data removal and recycling of the device at its end of life.Security Conquers AllThis new way of working comes with more opportunities for security vulnerabilities, making it critical to secure workers’ PCs.According to a recent study, more than three-quarters of organizations prioritize supply chain security during vendor selection to address counterfeit components, malware and firmware tampering. Solutions like Dell Technologies SafeSupply Chain help protect against tampering while the PC is in transport and prevent spyware or other malware from getting injected into the device’s hard drive.Securing below the operating system (OS) is also vital to the overall security of the device, as well as your business. We continue to find ways to bolster PC security with solutions like Dell SafeBIOS — because a compromised BIOS can potentially provide an attacker with access to information on your device.We also need to rethink security in a creative way. Not through patches and updates, but by offering PCs that use machine learning and AI to eradicate malware before it even settles. PCs should offer best-in-class security products and practices to lower the risk of having end-users accessing internal networks from home. For me, a renaissance in this area means I never question if my PC — or the information on it — is secure.The Time for a Renaissance Is NowWe have learned the PC is far from dead. It’s the gateway for us all to work, play and learn. Because of this intimacy, people expect more from their PC now than ever before — and we’re listening.We’re working on augmenting PCs with technologies like cloud, 5G and AI to offer smart, personalized and wonderful experiences. While we’ve long been on this journey, this “renaissance” moment gives us the opportunity to pause and rethink how we bring about this future.¹ IDClast_img read more

This Week’s Picks! Billy Porter, Sutton Foster & More

first_img Sutton Foster Laugh Out Loud at Living on LoveBegins April 1 at the Longacre TheatreThere’s lots to look forward to in Living on Love, the hilarious new comedy about the complications that erupt when a Maestro (Douglas Sills) and his diva wife (Renée Fleming) write dueling autobiographies—with foxy ghostwriters. You have opera superstar Fleming’s Broadway debut, the delightful Anna Chlumsky (fresh from You Can’t Take It With You), and hunky Jerry O’Connell…dropping trou. So if you like screwball comedies and sculpted bods, get going! Click for tickets! Kick Back with Billy PorterApril 3 on PBSGoing out, especially on Friday, can be a hassle. You’re tired, your paycheck is devoted to next week’s expired Easter chocolate, and you don’t feel like sidestepping tourists like Ben Vereen. Well, fear not. We have a fun, low-stress option to start your weekend. Tony-winning Kinky Boots favorite Billy Porter takes center stage in Broadway & Soul on Live from Lincoln Center, where he performs an array of songs while you lounge in track pants. Hey, you, trying to pull the perfect April Fool’s prank. Come on! How old are you, 12? Don’t spend your free time stocking up on whoopee cushions and dribbling glasses. Instead you can check out two new, highly anticipated shows, catch Sutton Foster on your TV screen and see Paige Davis and Amra-Faye Wright light up Chicago one more time. It’s no joking matter: get ready for this week’s picks! Get Younger with Sutton FosterPremieres March 31 on TV LandStay in tonight. Why? Because Sutton Foster is on your TV! In Younger, the Tony winner plays a 40-year-old single mom who, desperate for work, reinvents herself as a 26-year-old. Now she has to maintain the façade at a great new job with new colleagues (Hilary Duff and Miriam Shor). Another good sign, aside from Foster playing the lead? The series comes from Sex and the City creator Darren Star! We’re tuning in. Welcome Two Murderesses Back to ChicagoBegins March 30 at the Ambassador TheatreReason number 4,503,121 we love Broadway: Sometimes a long-running show will feature the return of a beloved former cast member. For several weeks, fans of Chicago will be in Xanadu. Starting tonight, Paige Davis and Amra-Faye Wright are back. Davis will reprise her performance as Roxie Hart through April 27. Wright will work the boards for longer as—surprise, surprise!—Velma Kelly; she’s there through July 26. Click for tickets! View Comments Star Files Celebrate Life at Airline HighwayBegins April 1 at the Samuel J. Friedman TheatreThe parking lot has many functions beyond its intended purpose: hang-out for noisy teens, forum for bad skateboarders, training ground for aspiring drivers… It’s also the setting for Lisa D’Amour’s Airline Highway, where New Orleans’ finest outcasts organize a pre-death funeral outside the old Hummingbird Hotel for former burlesque star Miss Ruby. The drama, which enjoyed an acclaimed run at Chicago’s Steppenwolf Theatre, stars Tony winner Julie White. Click for tickets!last_img read more